Spybot report: Is this a problem??

A Spybot scan shows the following registry change as a "threat". It refers
to what it says is a Microsoft product. What do I have here? Is this a
problem? Should I do something?

HKEY_USERS\S-1-5-21-631271675-1031378978-415638407-1006\Software\Microsoft\Internet Explorer\MainFeatureControl\FEATURE_LOCALMACHINE_
LOCKDOWN\iexplore.exe!=W=1

From Spybot report:
Company Product: Microsoft.Windows.Security.InternetExplorer
Threat: Security

Functionality
security settings for the Internet Explorer

Description
Security settings for the Internet Explorer can be changed by malware.
Some of the settings can also be changed by security software. In case you
have additional security softwre [SIC] installed, make sure that it is
working properly.
Microsoft.Windows.Security.InternetExplorer

ANY AND ALL SUGGESTIONS WILL BE APPRECIATED. THANKS!!

--
LIFE IS GOOD!!

Ron in Ri